Do I still need the typhoid vaccine if I grew up in an area where typhoid is endemic?

Yes, even if you grew up in an area where typhoid fever is endemic, it is still recommended that you receive the typhoid vaccine. This is because the vaccine provides additional protection against the disease and can reduce the risk of infection. It is important to note that even if you have had typhoid fever before, it is still possible to get infected again, and the vaccine can help prevent this from happening. It's also part of being a good global citizen. If you do travel, and you do become infected with typhoid, you may end up spreading it on to others. One interesting fact about typhoid is that it is often spread by people who are asymptomatic long-term typhoid carriers (remember Typhoid Mary).

There are two typhoid vaccines available in the U.S.:

Inactivated typhoid vaccine (injection): This vaccine contains killed Salmonella Typhi bacteria and is given as an injection. It is a one-dose, and provides protection against typhoid fever for approximately two years after which a booster dose is recommended.

Live attenuated typhoid vaccine (oral): This vaccine contains weakened live Salmonella Typhi bacteria and is given orally in the form of capsules. It requires a series of four capsules taken on alternate days and provides protection against typhoid fever for about five to seven years.

Both types of vaccines are effective in preventing typhoid fever, but the choice of vaccine depends on various factors such as age, health status, travel plans, and other considerations. It is important to consult with a healthcare professional to determine which type of vaccine is most appropriate for your specific situation.

It is recommended that you get the typhoid vaccine at least one to two weeks before you travel to give time for your body to build up immunity. Note that it takes about a week to complete the oral typhoid series, so if you do the oral vaccine you'll want to start it at least 2 weeks ahead of time.