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Is there a vaccine for cholera? Introducing Vaxchora

Yes, there is a vaccine for cholera available in the U.S. The vaccine was not available for a few years during the Covid-19 pandemic but we have it back in stock now at all of our clinics.

Cholera, a severe diarrheal disease caused by the bacterium Vibrio cholerae, continues to pose a threat to public health in many parts of the world. With its potential for rapid transmission and devastating impact on affected communities, the search for effective prevention strategies has been of utmost importance. In recent years, significant progress has been made, leading to the development of a vaccine specifically designed to combat cholera. In this blog post, we will explore the availability and key details of the cholera vaccine, with a focus on Vaxchora, the live, oral cholera vaccine approved for use in the United States.

Understanding Vaxchora

Vaxchora, the cholera vaccine, is a live, oral vaccine that provides protection against cholera caused by the O1 serogroup of Vibrio cholerae. Approved by the U.S. Food and Drug Administration (FDA) in 2016, Vaxchora has become a valuable tool in preventing cholera among individuals planning to travel to areas with ongoing cholera outbreaks.

Administration and Efficacy

Vaxchora is administered as a single-dose, drinkable vaccine. It contains live, attenuated (weakened) V. cholerae bacteria, which stimulate the body's immune response to build protection against future cholera infections. This vaccine is specifically recommended for individuals aged 18 to 64 years.

Effectiveness and Duration of Protection

Studies have shown that Vaxchora provides an estimated 90% efficacy against moderate to severe cholera cases within ten days of vaccination. It is important to note that the vaccine does not offer immediate protection. Therefore, individuals planning to travel to cholera-affected areas should receive the vaccine at least ten days before their departure.

Availability and Prescription

Vaxchora is available only by prescription and must be obtained from a healthcare provider. It is essential to consult with a healthcare professional or a travel medicine specialist well in advance of travel to determine if the vaccine is recommended based on the destination's risk profile and individual health considerations.

Limitations and Precautions

While Vaxchora is generally safe and well-tolerated, it is not suitable for everyone. Individuals with a weakened immune system or a history of severe allergic reactions should avoid the vaccine. Additionally, Vaxchora does not provide protection against non-O1 serogroups of Vibrio cholerae or other causes of diarrhea, such as rotavirus or traveler's diarrhea.

Other Preventive Measures

While Vaxchora provides a valuable layer of protection, it is crucial to emphasize that it should be used in conjunction with other preventive measures. Practicing good hygiene, such as frequent handwashing with soap and clean water, consuming safe food and water, and maintaining proper sanitation practices, remain essential in reducing the risk of cholera infection.


Vaxchora, the live, oral cholera vaccine, offers a significant advancement in cholera prevention for individuals planning to travel to areas with ongoing cholera outbreaks. Its high efficacy and convenience make it a valuable tool in the fight against cholera. However, it is important to remember that the vaccine should be part of a comprehensive approach to prevention, including adherence to proper hygiene and sanitation practices. Consultation with a healthcare provider or travel medicine specialist is crucial to determine the suitability and timing of vaccination based on individual circumstances. Stay informed, stay protected, and contribute to the global efforts to eradicate cholera.


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